MCE 癌症免疫治疗化合物 Cancer Immunotherapy.docx

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MCE 癌症免疫治疗化合物 Cancer Immunotherapy.docx

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www.MedChemE

MedChemExpress

Immunology

ProductHandbook

EarlyNeoplasia

EarlyInfection

PMN

Macrophage

PMN

Th1cell

Tumorcells

Th1cell

Parenchymalcells

MatureTumor

ProtractedInfection

PD-L1

PD-1

Macrophage

Exhausted

Th2cell

Th1cell

Reactivenitrogen

PD-L1

species

Interleukin-10

Th2cell

PD-L1

Myeloid-derived

suppressorcells

Interleukin-10

Reactivenitrogen

Interleukin-10

species

T-regulatory

TGF-β

cell

Interleukin-10

Apoptotic

cell

PMN

Th1cell

PD-L1

Exhausted

Macrophage

TGF-β

PD-L1

Th1cell

Tumorcells

PD-1

PD-L1

Exhausted

Th1cell

PD-L1

Reference:

RichardS.Hotchkiss,M.D.,

andLyleL.Moldawer,Ph.D.

ParallelsbetweenCancer

andInfectiousDisease.

causinghumancoronavirus

Figure1.Structureofrespiratorysyndrome

Lipidbilayer

Membraneglycoprotein(M)

Spikeprotein(S)

RNA

Envelopeglycoprotein(E)

Nucleocapsidprotein

MCE

MasterofBioactiveMolecules

Immunology

Theimmunesystemisanetworkconsistsofmultiplecells,tissues,andorgansthatworktogethertoprotectanorganismfromdiseases.Immunesystemrecognizesselfandnon-self,andrespondstoawidevarietyofpathogen,fromviruses,bacteria,fungi,parasitestocancercells.

Humanhavetwomajorsubsystemofimmunesystem:theinnateimmunesystemandtheadaptiveimmunesystem.Theinnateimmunesystem,thesystemwebornwith,provideapreconfiguredresponsetobroadgroupsofstimuli,andcanrespondquicklyduringearlyonsetofinfection.Theadaptiveimmunesystemonlydevelopedwhenourbodyisexposedtothepathogen,andcanactwithgreatspecificity.

Inabalancedimmunesystem,immunecellsdistinguish“non-self”from“self”,innateimmunityandadaptiveimmunitycollaboratesefficientlytowipeoutinvaders.Whiledisorderedimmunesystemareleadingcausesofmultiplemajordiseases:inactivatedimmunesysteminduceinfectiousdi