原创力文档- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
整理pptFigure?22-43?Thegrowthofcartilage.????Thetissueexpandsasthechondrocytesdivideandmakemorematrix.Thefreshlysynthesizedmatrixwithwhicheachcellsurroundsitselfisshadeddarkgreen.Cartilagemayalsogrowbyrecruitingfibroblastsfromthesurroundingtissueandconvertingthemintochondrocytes.
Figure?22-44?Depositionofbonematrixbyosteoblasts.????Osteoblastsliningthesurfaceofbonesecretetheorganicmatrixofbone(osteoid)andareconvertedintoosteocytesastheybecomeembeddedinthismatrix.Thematrixcalcifiessoonafterithasbeendeposited.Theosteoblaststhemselvesarethoughttoderivefromosteogenicstemcellsthatarecloselyrelatedtofibroblasts.
Figure?22-45?Anosteoclastshownincross-section.????Thisgiant,multinucleatedcellerodesbonematrix.Theruffledborderisasiteofsecretionofacids(todissolvetheboneminerals)andhydrolases(todigesttheorganiccomponentsofthematrix).Osteoclastsvaryinshape,aremotile,andoftensendoutprocessestoresorbboneatmultiplesites.Theydevelopfrommonocytesandcanbeviewedasspecializedmacrophages.(FromR.V.Krsti′c,UltrastructureoftheMammalianCell:AnAtlas.Berlin:Springer,1979.)
Figure?22-46?Theremodelingofcompactbone.????Osteoclastsactingtogetherinasmallgroupexcavateatunnelthroughtheoldbone,advancingatarateofabout50mmperday.Osteoblastsenterthetunnelbehindthem,lineitswalls,andbegintoformnewbone,depositinglayersofmatrixatarateof1or2mmperday.Atthesametimeacapillarysproutsdownthecenterofthetunnel.Thetunnelwilleventuallybecomefilledwithconcentriclayersofnewbone,withonlyanarrowcentralcanalremaining.Eachsuchcanal,besidesprovidingarouteofaccessforosteoclastsandosteoblasts,containsoneormorebloodvesselsbringingthenutrientsthebonecellsmusthavetosurvive.Typically,about5-10%oftheboneinahealthyadultmammalisrepla
文档评论（0）