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§8.1Nucleotides§8.2NucleicAcids§8.3NucleicAcidChemistry§8.4OtherFunctionsofNucleotides§8Nucleotidesnucleicacids
b-RibonucleotideD-
b-D-deoxyribonucleotide
ConfigurationofRiboseinNucleotides
Basesinnucleotides
ModificationsofNucleotides(1)
ModificationsofNucleotides(2)
§8.1Nucleotides§8.2NucleicAcids§8.3NucleicAcidChemistry§8.4OtherFunctionsofNucleotides§8Nucleotidesnucleicacids
§8.2NucleicAcidsBriefHistoryaboutDNADNAStructureRNAStructure
1869,Miescherisolatesnuclein1928,GriffithfindsStreptococcustransformation1944,AverydiscoveredthatDNAwasthegeneticmaterialBy1947,ChargaffhaddevelopedaseriesofrulesbasedonasurveyofDNAcompositioninorganismsEarlyin1950s,WilkinsFranklinusedX-raycrystallographytostudythestructureofDNA1952,HersheyfarthershowedthatDNAwasthegeneticmaterial1953,WatsonCrickproposethedouble-helicalstructureofDNA......BriefHistoryaboutDNA
1928,Griffith’stransformationexperiment(1)
1928,Griffith’stransformationexperiment(2)
1928,Griffith’stransformationexperiment(3)
1928,Griffith’stransformationexperiment(4)Return
1944,Avery-MacLeod-McCartyexperimentReturn
Franklin’sX-raypictureforDNAReturn
1952,AlfredD.HersheyMarthaChaseexperimentReturn
Return
§8.2NucleicAcidsBriefHistoryaboutDNADNAStructureRNAStructure
DNAStructureDoubleHelix
DNAStructure:doublehelix
Inadditiontohydrogenbonds,base-stackinginteractions(hydrophobicinteraction,vanderWaalsforce,dipole-dipoleinteraction)areveryimportantinstabilizingDNAstructure.
MajorgrooveMinorgrooveA-DNAB-DNAZ-DNAAllcontain21basepairsDNAStructure:threehelixforms(1)
A-DNAB-DNAZ-DNAAllcontain21basepairsDNAStructure:threehelixforms(2)
A-DNAB-DNAZ-DNAAllcontain21basepairsDNAStructure:threehelixforms(3)
DNAStructure:threehelixforms(5)B-DNAisthemoststablestructureinphysiologicalcondition.WhetherA
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