microRNA-214在膀胱癌中表达的生物学功能、调控机制及临床应用研究中期报告.docxVIP

microRNA-214在膀胱癌中表达的生物学功能、调控机制及临床应用研究中期报告

摘要：

膀胱癌是盛行于全球的常见恶性肿瘤，严重威胁人类健康。目前，膀胱癌的发病和发展机制尚未完全明确。研究发现，微小RNA-214（microRNA-214，miR-214）在膀胱癌中具有重要的生物学功能和临床应用价值。本文综述了目前针对miR-214在膀胱癌中表达的生物学功能、调控机制及临床应用方面的研究进展，重点介绍了miR-214在膀胱癌中作用的分子机制和潜在治疗靶点。通过系统回顾国内外相关文献和实验室研究成果，发现miR-214在膀胱癌中具有抑制细胞增殖、诱导细胞凋亡及调控细胞周期的作用，其过度表达可抑制膀胱癌的进展和转移。此外，miR-214通过调节TGF-β信号通路、Akt/mTOR通路、Wnt信号通路等重要信号通路影响膀胱癌的发生和发展。因此，miR-214可能成为膀胱癌治疗的潜在靶点和生物标志物。

关键词：膀胱癌；miR-214；生物学功能；调控机制；临床应用

Abstract:

Bladdercancerisacommonmalignanttumorthatseriouslythreatenshumanhealthglobally.Atpresent,themechanismofitsoccurrenceanddevelopmentisnotfullyunderstood.StudieshavefoundthatmicroRNA-214(miR-214)hasimportantbiologicalfunctionsandclinicalapplicationvalueinbladdercancer.Thisarticlereviewstheresearchprogressonthebiologicalfunctions,regulatorymechanisms,andclinicalapplicationsofmiR-214expressioninbladdercancer,focusingonthemolecularmechanismsandpotentialtherapeutictargetsofmiR-214inbladdercancer.Throughasystematicreviewofrelevantdomesticandforeignliteratureandlaboratoryresearchresults,itwasfoundthatmiR-214hastheabilitytoinhibitcellproliferation,inducecellapoptosis,andregulatecellcycleinbladdercancer.Itsoverexpressioncaninhibittheprogressionandmetastasisofbladdercancer.Inaddition,miR-214affectstheoccurrenceanddevelopmentofbladdercancerbyregulatingimportantsignalingpathwayssuchastheTGF-βsignalingpathway,Akt/mTORpathway,andWntsignalingpathway.Therefore,miR-214maybecomeapotentialtargetforbladdercancertreatmentandabiomarker.

Keywords:bladdercancer;miR-214;biologicalfunction;regulatorymechanism;clinicalapplication