脑网络文献学习mmc network.pptx

下载文档

0
0
约1.96万字
约 28页
2024-06-19 发布于北京
举报
版权申诉
保障服务

脑网络文献学习mmc network.pptx

1、本文档共28页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

NATUREREVIEWS|NEUROSCIENCE,2014Speaker:MMC

Abstract|Modernnetworksciencehasrevealedfundamentalaspectsofnormalbrain-networkorganization,suchassmall-worldandscale-freepatterns,hierarchicalmodularity,hubsandrichclubs.Thenextchallengeistousethisknowledgetogainabetterunderstandingofbraindisease.RecentdevelopmentsintheapplicationofnetworksciencetoconditionssuchasAlzheimer’sdisease,multiplesclerosis,traumaticbraininjuryandepilepsyhavechallengedtheclassicalconceptofneurologicaldisordersbeingeither‘local’or‘global’,andhavepointedtotheoverloadandfailureofhubsasapossiblefinalcommonpathwayinneurologicaldisorders.

Modernnetworksciencehasintroducedexcitingnewopportunitiesforunderstandingthebrainasacomplexsystemofinteractingunits.Normalbrainnetworksarecost-efficientsmall-worldnetworks,arealsoapproximatelyscale-free,withapreponderanceofhighlyconnectedhubareasthattogetherconstitutea‘richclub’.Inaddition,brainnetworksdisplayhierarchicalmodularity,inwhichthemodulescorrespondtomajorfunctionalsystems,suchasmotor,sensoryandassociationnetworks.Thesepatternsofbrain-networkorganizationariseduringdevelopment,arestronglyregulatedbygenesandareimportantforcognitivefunction.

Theimprovedunderstandingofnormalbrainnetworkorganizationhasmadeitpossibletoaddressnetworkchangesinneurologicalandpsychiatricdiseases.[dementia,epilepsy,schizophrenia,traumaticbraininjury(TBI),multiplesclerosis(MS),cerebrovasculardisease,comaandmanyotherconditions.]Thesestudiesarechallengingtheideathatbraindiseaseinvolveseither‘local’or‘global’pathology.[AD,braintumoursorvascularlesions]Thesefindingscannowbereproducedinincreasinglyrealisticmodelsoflarge-scalestructuralandfunctionalbrainnetworks.Thenewfieldof‘computationalneurology’hasthepotentialtoprovidearational