医脉通-指南非小细胞肺癌基因突变检测共识.pdfVIP

MEETINGSUMMARY

ConsensusforEGFRMutationTestinginNon-smallCell

LungCancer

ResultsfromaEuropeanWorkshop

RobertPirker,MD,*FelixJ.F.Herth,MD,PhD,F,†KeithM.Kerr,MD,FRCPath,‡

MartinFilipits,PhD,*MiquelTaron,PhD,§DavidGandara,MD,¶FredR.Hirsch,MD,#

DominiqueGrunenwald,MD,**HelmutPopper,MD,††EgbertSmit,MD,PhD,‡‡

ManfredDie,MD,§§AntonioMarchetti,MD,PhD,ChristianManegold,MD,¶¶

PeterSchirmacher,MD,##MichaelThomas,MD,PhD,†RafaelRosell,MD,PhD,§

FedericoCappuzzo,MD,***andRolfStahel,MD†††;onBehalfoftheEuropeanEGFRWorkshopGroup

celllungcancer(NSCLC).Patientsharboringthesemutationsin

Introduction:Activatingsomaticmutationsofthetyrosinekinase

theirtumorsshowexcellentresponsetoEGFRtyrosinekinase

ofepidermalgrowthfactorreceptor(EGFR)haverecently

inhibitors(EGFR-TKIs).TheEGFR-TKIgefitinibhasbeenap-

beencharacterizedinasubsetofpatientswithadvancednon-small

provedinEuropeforthetreatmentofadultpatientswithlocally

advancedormetastaticNSCLCwithactivatingmutationsofthe

*MedicalUniversityofVienna,Vienna,Austria;†ThoraxklinikUniversityofEGFRTK.Bec