维生素D相关文献In sickness and in health_ pivotal role of vitamin D.pdf

维生素D相关文献In sickness and in health_ pivotal role of vitamin D.pdf

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Review

Insicknessandinhealth:pivotalroleofvitaminD

1,2111134

NoraNikolacGabaj*,AdrianaUnic,MarijanaMiler,TomislavPavicic,JelenaCulej,IvanBolanca,DavorkaHermanMahecic,

LaraMilevojKopcinovic1,AlenVrtaric1

1DepartmentofClinicalChemistry,SestremilosrdniceUniversityHospitalCenter,Zagreb,Croatia

2FacultyofPharmacyandBiochemistry,UniversityofZagreb,Zagreb,Croatia

3DepartmentofHumanReproduction,SestremilosrdniceUniversityHospitalCenter,Zagreb,Croatia

4DepartmentforEndocrinology,DieabetesandMetabolism,SestremilosrdniceUniversityHospitalCenter,Zagreb,Croatia

*Correspondingauthor:nora.nikolac@

Abstract

Withinthelastseveralyears,frequencyofvitaminDtestinghasmultipliedsubstantiallyallovertheworld,sinceithasbeenshowntohaveanim-

portantroleinmanydiseasesandconditions.Eventhoughliquidchromatography-tandemmassspectrometry(LC-MS/MS)hasbeenidentifiedas

“goldstandard”methodforvitaminDmeasurement,mostlaboratoriesstilluseimmunochemistrymethods.Besidesanalyticalproblems(hydrop-

hobicity,lowcirculatingconcentrations,abilitytobindtolipids,albuminsandvitaminDbindingprotein,presenceofmultiplevitaminDmetaboli-

tesandvariableratiosof25(OH)Dand25(OH)Dintheblood),vitaminDshowsgreatpreanalyticalvariability,sinceitsconcentrationisdrastically

23

influencedbyseasonalchanges,exposuretosun,typeofclothesorsunblockcreams.VitaminDismostlymeasuredinserumorplasma,butnew

studiesareshowingimportanceofmeasuringvitaminDinpleuraleffusions,breastmilk,urine,synovialfluidandsaliva.Besidesthemainroleincal-

ciumhomeostasisandbonemetabolism,manystudieslinkedvitaminDdeficiencywi

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