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Irondeficiencyanemia
CONTENTSINTRODUCTIONETIOLOGY/PATHOGENESISMANIFESTATIONSLABORATORYFINDINGSDIAGNOSISDIFFERENTIALTREATMENTCASEREPORT
Irondeficiencyanemia(IDA)Theanemiacausedbyinsufficientdietaryironuptake,bleeding,etal,inwhichtheironstorageandhemoglobinsynthesisdecreased.Irondeficiencyistheleadingcauseofanmeiaworldwide.hemoglobinhemeglobinFe++protoporphyrin
Serumiron
Causes
MANIFESTATIONSMANIFESTATIONSPrimarydiseaseanemia
Menifestationofanemia1,commonmenifestation:pale,weak,dizzy,tinnitus,palpitation2,specialmenifestation:
Tests---morphology---bloodMCV80flMCH26pgMCHC32%
Tests---morphology---bonemarrow
Tests---ironmetabolismSerumironTotalironbindingcapacity,TIBCTransferrinsatuationSerumferritinFEP(freeerythrocyteprotoporphyrin)
DIAGNOSISThreestages1,irondepletion:serumferritin,serumironnormal2,latentirondeficiencyserumiron,serumferritin,FEP,TIBC,HBnormal3,IDA
DIFFERENTIAL1,thalassemia2,anemiaofchronicdiseaseserumiron,serumferritin,TIBCnormal,ringedsideroblast3,ringedsiderblastanemiaringedsideroblast,15%
treatmentTreatmentofprimarydiseaseIronsupplementation(TargetHb-presentHb)*kg*0.33(TargetHb-presentHb)*kg*0.24+500
TreatmentresponseRet:d7-10Hemoglobin:week2Hemogolbin:1-2monthlaternormalFerritin:continuesupplement3months
Casereport A20-year-oldfemalepresentedwithfatigue,paleinAugust2014.ShewasadmittedtoThe1stAffiliated,GMU.Physicalexaminationfoundthatnosternumtendernessandnoenlargementofliverandspleen.
TEST Shepresentedwithandecreasedleukocytecountof2.5×109/L,anaemiawithhaemoglobinof54g/l,RBCcountof3.4×1012/L,MCV55.9fL,MCH:15.9pg,MCHC:284g/L.Plateletcountof343×109/L. Serumiron6.2umol/L,TIBC:89.1umol/LSerumferritin:18.94ng/mLCD55/59normal,thalassemiagenetestnormal
dianosisIronDeficiencyAnemiaWhatwasthecauseofIDA?decreaseofintake: sheeatedlittlemeat.bloodloss: hermenstruationwasnormal.gast
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