Capravirine-S-1153-生命科学试剂-MCE.pdf

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Capravirine

Cat.No.:HY-14294

CASNo.:178979-85-6

Synonyms:S-1153

分⼦式:C₂₀H₂₀Cl₂N₄O₂S

分⼦量:451.37

作⽤靶点:ReverseTranscriptase

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Capravirine是具有⼝服活性的⾮核苷类逆转录酶抑制剂(NNRTI)，具有强效的抗病毒活性。Capravirine能够

抑制对核苷/核苷酸逆转录酶抑制剂以及其他NNRTI耐药的HIV-1株的复制。Capravirine通过细胞⾊素P450

酶CYP3A4进⾏代谢[1][2]。

REFERENCES

[1].BuHZ,etal.Metabolismandexcretionofcapravirine,anewnon-nucleosidereversetranscriptaseinhibitor,aloneandincombination

withritonavirinhealthyvolunteers.DrugMetabDispos.2004Jul;32(7):689-98.

[2].GewurzBE,etal.Capravirine,anonnucleosidereverse-transcriptaseinhibitorinpatientsinfectedwithHIV-1:aphase1study.JInfect

Dis.2004Dec1;190(11):1957-61.

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