C-Type-Natriuretic-Peptide-1-53-Porcine-Rat-mouse-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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C-TypeNatriureticPeptide(1-53),Porcine,Rat,mouse

Cat.No.:HY-P10720

CASNo.:129405-72-7

分⼦式:C₂₅₁H₄₁₄N₈₂O₇₀S₃

分⼦量:5796.68

Sequence:Asp-Leu-Arg-Val-Asp-Thr-Lys-Ser-Arg-Ala-Ala-Trp-Ala-Arg-Leu-Leu-His-Glu-His-

Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Gly-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Ph

e-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys(Disulfidebridg

e:Cys37-Cys53)

SequenceDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC

Shortening:(Disulfidebridge:Cys37-Cys53)

作⽤靶点:EndogenousMetabolite

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateof

Analysis.

BIOLOGICALACTIVITY

⽣物活性C-TypeNatriureticPeptide(1-53),Porcine,Rat,mouse是⼀种颗粒鸟苷酸环化酶B(pGC-B)激活剂，在内⽪细

胞、肾脏和⼼脏中⼤量表达。C-TypeNatriureticPeptide(1-53),Porcine,Rat,mouse可以通过产⽣第⼆信使

cGMP，在⼈⼼脏和肾脏成纤维细胞中介导强效的抗纤维化作⽤。

REFERENCES

[1].ChenY,etal.C53:AnovelparticulateguanylylcyclaseBreceptoractivatorthathassustainedactivityinvivowithanti-fibroticactionsin

humancardiacandrenalfibroblasts.JMolCellCardiol.2019May;130:140-150.

McePdfHeight