复方钩藤降压片干预高血压左心室肥厚血浆代谢组学的通路分析.pdfVIP

窑药物与临床窑

中国医药导报2019年10月第16卷第30期

复方钩藤降压片干预高血压左心室肥厚

血浆代谢组学的通路分析

冯宇俞赟丰周曼丽王健章张家齐钱舒乐简维雄

湖南中医药大学中医学院袁湖南长沙410208

[摘要]目的探讨复方钩藤降压片干预自发性高血压左心室肥厚大鼠血浆代谢组学的通路遥方法采用KEGG尧

HMDB尧MetaboAnalyst网络软件等方法展开对信号通路尧代谢产物转运蛋白尧相关的酶或分子注释及相关性质和

代谢产物路径可视化的研究遥结果MetaboAnalyst分析生物代谢通路显示袁11个代谢产物参与了14条代谢路

径遥其中2条通路渊磷酸戊糖路径尧嘌呤代谢冤的影响值较高渊P约0.05冤遥结论复方钩藤降压片干预自发性高血

压左心室肥厚大鼠磷酸戊糖路径和嘌呤代谢生物合成通路参与其病理过程遥

[关键词]复方钩藤降压片曰代谢通路曰磷酸戊糖途径曰嘌呤代谢

[中图分类号]R285.5[文献标识码]A[文章编号]1673-7210渊2019冤10渊c冤-0126-05

Pathwayanalysisofplasmametabolomicsinthetreatmentofhypertensive

leftventricularhypertrophywithUncariaCompoundAntihypertensive

Tablets

FENGYuYUYunfengZHOUManliWANGJianzhangZHANGJiaqiQIANShuleJIANWeixiong

CollegeofTraditionalChineseMedicine,Hu忆nanUniversityofChineseMedicine,Hu忆nanProvince,Changsha410208,

China

[Abstract]ObjectiveToexploretheplasmametabolomicspathwayofUncariaCompoundAntihypertensiveTabletsin

ratswithspontaneoushypertensionandleftventricularhypertrophy.MethodsKEGG,HMDB,MetaboAnalystandother

methodswereusedtocarryouttheresearchonthesignalpathway,metabolitetransporter,relatedenzymeormolecular

annotationandrelatedproperties,aswellasthevisualizationofmetabolitepathway.ResultsThemetabolicpathways

analyzedbyMetaboAnalystshowedthat11metabolitesparticipatedin14metabolicpathways.Influencevaluesof2

pathways(pentosephosphatepathwayandpurinemetabolism)werehigher(P约0.05).ConclusionUncariaCompound

Antihypertensivetabletintervenesthepathologicprocessesofpentosephosphatepathwayandpurinemetabolicbiosyn鄄

thesispathwayinspontaneoushypertensiveleftventricularhypertrophyrats.

[Keywords]UncariaCompoundAntihypertensiveTablets;Metabolicpathway;Pentosephospha