中枢神经特异蛋白对检测老年性痴呆的临床价值.pdfVIP

中枢神经特异蛋白对检测老年性痴呆的临床价值

凌迎春;周月琴;段迪;胡玲敏

【摘要】目的分析中枢神经特异蛋白(s100β蛋白)对检测老年性痴呆的临床价值.

方法选取300例老年性痴呆患者作为观察组,另选取200名同期、同年龄段体检

健康者作为对照组,采集2个组血液标本,并应用酶联免疫吸附试验(ELISA)检测2个

组血清s100β蛋白水平,应用简易精神状态量表(MMSE)评价2个组认知功能,并分

析s100β蛋白与患者MMSE评分间的关系.结果观察组血清中s100β蛋白水平为

(82.07±11.58)pg/mL,明显高于对照组(49.16±2.23)pg/mL(P0.05);s100β蛋白

在老年性痴呆检测中的灵敏度为71.35%,特异度为84.67%;观察组的MMSE评分

[(15.93±4.68)分]明显低于对照组[(26.17±3.02)分](P0.05);s100β蛋白与MMSE

评分呈负相关[相关系数(r)=-0.276,P0.05].结论s100β蛋白在老年性痴呆检测中

的灵敏度及特异度均较高,其血清水平越高者,痴呆程度往往越严重,可作为临床辅助

诊断老年性痴呆的指标.%ObjectiveToevaluatetheroleofcentralnervous

systemspecificprotein(s100βprotein)determinationinseniledementia.

MethodsAtotalof300patientswithAlzheimersdiseasewere

enrolled,and200healthysubjectswithsameagewereenrolledashealthy

controlgroup.Theirbloodsampleswerecollected,andserums100β

proteinlevelsweredeterminedbyenzyme-linkedimmunosorbent

assay(ELISA).Thecognitivefunctionwasevaluatedbymini-mentalstate

examination(MMSE),andtherelationshipbetweens100βproteinand

MMSEscorewasevaluated.ResultsThelevelofserums100βproteinin

observationgroupwas(82.07±11.58)pg/mL,anditwashigherthanthatin

healthycontrolgroup[(49.16±2.23)pg/mL,P0.05].Thesensitivityofs100β

proteindeterminationwas71.35%,andthespecificitywas84.67%.The

MMSEscoreinobservationgroupwas15.93±4.68,anditwaslowerthan

thatinhealthycontrolgroup(26.17±3.02,P0.05).Therewasanegative

correlationbetweens100βproteinandMMSEscore[correlation

coefficient(r)=-0.276,P0.05].ConclusionsThedeterminationofs100β

proteinforseniledementiahashighsensitivityandspecificity.Thehigher

serums100βproteinlevelis,moreseriousthedegreeofseniledementiais.

Itcanbeusedfortheauxiliarydiagnosisofseniledementia.

【期刊名称】《检验医学》

【年(卷),期】2017(032)011

【总页数】3页(P1021-1023)

【关键词】中枢神经特异蛋白;老年性痴呆;酶联免疫吸附试验

【作者】凌迎春;周月琴