3-O-Methyltolcapone-Standard-生命科学试剂-MCE.pdf

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3-O-Methyltolcapone(Standard)

Cat.No.:HY-100642R

CASNo.:134612-80-9

分⼦式:C₁₅H₁₃NO₅

分⼦量:287.27

作⽤靶点:COMT

作⽤通路:MetabolicEnzyme/Protease;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性3-O-Methyltolcapone(Standard)是3-O-Methyltolcapone的分析标准品。本产品⽤于研究及分析应⽤。3-O-

Methyltolcapone(Ro40-7591)是Tolcapone的代谢产物。Tolcapone是⼀种⼝服活性，可逆，选择性和有效

的COMT抑制剂。Tolcapone可穿过⾎脑屏障，可⽤于帕⾦森⽒病的研究。

IC50TargetCOMT[1][2]

REFERENCES

[1].JorgaK,etal.Metabolismandexcretionoftolcapone,anovelinhibitorofcatechol-O-methyltransferase.BrJClinPharmacol.1999

Oct;48(4):513-20.

[2].CeravoloR,etal.18F-dopaPETevidencethattolcaponeactsasacentralCOMTinhibitorinParkinsonsdisease.Synapse.2002Mar

1;43(3):201-7.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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