人体寄生虫学-schistosomiasis.ppt

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Schistosomiasis1

800millionsliveinendemicregion200millionsinfectedMortality2,800,0002

ThreeclinicalimportantschistosomesSpeciesResidentLocationLesionoftissueDistributionS.mansonimesentericrectalveinLiver,intestineAfricaSouthAmericaS.haematobiumperivesicalvenousplexusofthebladder,uretersandkidneysthroughthehemorrhoidalplexusUrinarybladderReproductiveorgansAfricaMiddleEastS.japonicumPortal-mesentericveinLiver,intestineAsia3

Matedworm♂:1-2cm,flattenedandwhite♀:1.2-2.8cm,cylindricalanddust-color4

S.mansoniworms:themalewormcarriesthefemaleinthe“gynecophoralcanal”5

gutovarytestesinseriesoviductuterus6

7

EggMiracidium8

Hatchingofmiracidiumfromegg:water:lowosmoticpressure;temperature:hatchingisinhibitedwhentemperatureislowerthan100Corhigherthan370C;illumination:hatchingisinhibitedunderdark;9

Cercaria(尾蚴)Escapeofcercariafromsnail10

Sheddingofcercariafromsnail:water:freshwatertemperature:200C~250Cillumination:11

migratingthroughskinmigrationfromthelungtotheportalvein12

Adult→Egg→Miracidium→Sporocyst→Cercaria→Adult(successivegenerations)OncomelaniaHumans,mammaliansSkin—lymphatic(blood)vessel—heart(lung)--mesentericartery--capillaries--portalvein(copulation)--superiormesentericvenules13

PathogenesisandSymptomology1.Cercaria:cercarialdermatitis—ⅠⅣhypersensitivereactionItchyrash,erythema,transient2.Schistosomulaadults:inflammationoflungandvein,andasympyomatic14

SwimmersItchorRicePaddyItch?Swimmersitch,duckitch,orcercarialdermatitis,isashort-term,immunereactionoccurringintheskinofpeoplethathavebeeninfectedbywater-bornetrematodeparasites.Symptoms—itchy,raisedpapules,commonlyoccurwithinhoursofinfectionanddonotgenerallylastmorethanaweek.Pathogen—Mostcasesarecausedbyp

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