肺癌的诊断治疗进展课件.ppt

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AdvancesintheManagementofNonSmallCellLungCancerThierryM.Jahan,MDThoracicOncologyProgramUCSFDillerFamilyComprehensiveCancerCenter肺癌的诊断治疗进展

PresenterDisclosures Personalfinancialrelationshipswithcommercialinterestsrelevanttothispresentationduringthepast12months:Researchsupport:EliLilly,Genetech,OSIpharmaceuticalsPersonalfinancialrelationshipswithnon-commercialinterests(e.g.,governmentorothernonprofitfunding)relevanttothispresentation,withinpast12months:Relevantinstitutionalfinancialinterests:Personalfinancialrelationshipswithtobaccoindustryentitieswithinthepast3years:Norelationshiptodisclose肺癌的诊断治疗进展

Jemal,CACancerJClin2008;58:71Cancer IncidenceDeathsColon 108,070 49,960Breast 184,450 40,930Prostate 186,320 28,660Total 478,840 119,550NSCLCEpidemiologyLung 215,020161,840Statisticsfor2008肺癌的诊断治疗进展

NSCLC:StageatDiagnosisStageIV40%StageI10%StageII20%StageIIIA15%StageIIIB15%Ettingeretal.Oncology.1996;10:81-111.肺癌的诊断治疗进展

AdaptedwithpermissionfromSchillerJHetal.NEnglJMed.20021yrsurvivalplateauatabout35-40%Noclearefficacybenefitfornon-platinumcombinationsortripletcombinationsNewparadigmisneededCisplatin/PaclitaxelCisplatin/GemcitabineCisplatin/DocetaxelCarboplatin/Paclitaxel1.00.80.60.40.20.0051015202530MonthsStage

IIIB/IV

Patient

Survival,

%WehadreachedaCeilingforImprovedBenefit

ofCytotoxicChemotherapyinAdvancedNSCLCECOG1594肺癌的诊断治疗进展

PlatinumDoubletChemotherapyinAdvancedNSCLC11.NCCNNon-smallCellLungCancerClinicalPracticeGuideline,v.2.2008.Availableat:2.Frascietal.JClinOncol.1999;17:2316-23253.Kellyetal.ClinCancerRes.2000;6:3474-3479.Overallresponse25%-35%Time-to-progression4-6monthsMediansurvival8-12months1-yearsurvival30%-40%2-yrsurvival10%-15%FailedParadigms:TripletCytotoxicChemotherapy2,3Non-PlatinumChemotherapySingleAgentChemotherapy肺癌的诊断治

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