B型钠尿肽在冠心病严重程度及预后评估中的应用 .pdfVIP

B型钠尿肽在冠心病严重程度及预后评估中的应用

张健;张力;汪萍;张广慧;王连升

【摘要】ObjectiveToinvestigatetheapplicationandroleofB-type

natriureticpeptide(BNP)determinationintheevaluationofseverityand

prognosisofcoronaryarterydisease.MethodsAccordingtotheresultof

angiograph,350patientssufferingthechestpainwereclassifiedintonon-

coronaryarterydiseasegroup(95patients)andcoronaryarterydisease

group(256patients)[stableangina(SA)group(111patients)andacute

coronarysyndrome(ACS)group(145patients)].Thegeneralinformation,

thenumberofpathologicalchangebranchesandtheGensiniscoreof

patientswererecorded.ThelevelofBNPwasdetectedby

chemiluminescenceimmunoassay.Themajoradversecardiacevents

(MACE)wererecordedin1yearfollow-upperiod.Thedifferencesofthe

levelofBNPwiththenumberofpathologicalchangebranchesandthe

MACEindifferentgroupswereanalyzed.ResultsThecoronaryartery

diseasegrouphadthehigherlevelofBNP[(137.95±21.58)pg/mL]than

thatofnon-coronaryarterydiseasegroup[(89.05±9.18)pg/mL,P＜0.

01].ThelevelofBNPintheACSpatients[(177.83±22.16)pg/mL]was

dramaticallyhigherthanthatinSApatients[(121.17±19.98)pg/mL,P＜

0.01].ThelevelofBNPinthepatientswiththreestenosisbrancheswas

higherthanthatoftwostenosisbranches,andthelevelofBNPwashigher

intwostenosisbranchesthaninsingleonebranch(P＜0.05).According

totheBNPlevel,theGensiniscoreswereclassifiedintolowgroup(29.10

±4.54),middlegroup(37.76±6.91)andhighgroup(58.46±3.71)with

statisticalsignificance(P＜0.05),whichtheirBNPlevelswere112.05±9.52,

147.56±17.12and(180.03±22.57)pg/mLinthelow,middleandhigh

groupsrespectively.Therewere29MACEduringthefollow-upperiod,

including3caseswithnon-cardiacdisease,12caseswithacuteand

selectiveangiograph,9casesadministratedthesecondpercutaneous