Disopyramide-hydrochloride-Dicorantil-hydrochloride-生命科学试剂-MCE.pdf

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Disopyramidehydrochloride

Cat.No.:HY-12533B

CASNo.:54687-36-4

Synonyms:Dicorantilhydrochloride;SC-7031hydrochloride

分⼦式:C₂₁H₃₀ClN₃O

分⼦量:375.94

作⽤靶点:SodiumChannel;PotassiumChannel

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Disopyramidehydrochloride是⼀种⽤于研究室性和房性⼼律失常的IA类抗⼼律失常试剂。Disopyramide

hydrochloride阻断⼼肌快速内向钠电流(sodiumcurrent)，延长⼼肌动作电位持续时间。Disopyramide

hydrochloride抑制HERG编码的钾通道(potassiumchannels)。Disopyramidehydrochloride也表现出复杂

的蛋⽩质结合，并具有强⼤的负性肌⼒作⽤。

客户使⽤本产品发表的科研⽂献

•JMedChem.2021Mar11;64(5):2725-2738.

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REFERENCES

[1].LASiddoway,etal.ClinicalPharmacokineticsofDisopyramide.ClinPharmacokinet.May-Jun1986;11(3):214-22.

[2].AAPaul,etal.InhibitionofHERGPotassiumChannelCurrentbytheClass1aAntiarrhythmicAgentDisopyramide.BiochemBiophys

ResCommun.2001Feb9;280(5):1243-50.

[3].SVJones