3-Amino-4-6-dimethylpyridine-5A-DMP-生命科学试剂-MCE.pdf

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3-Amino-4,6-dimethylpyridine

Cat.No.:HY-W004883

CASNo.:1193-71-1

Synonyms:5A-DMP

分⼦式:C₇H₁₀N₂

分⼦量:122.17

作⽤靶点:E1/E2/E3Enzyme;DNA/RNASynthesis

作⽤通路:MetabolicEnzyme/Protease;CellCycle/DNADamage

储存⽅式:4°C,protectfromlight

*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)

BIOLOGICALACTIVITY

⽣物活性3-Amino-4,6-dimethylpyridine(5A-DMP)是⼀种UHRF1抑制剂，靶向UHRF1TTD结构域的Arg-binding

cavity位点。3-Amino-4,6-dimethylpyridine通过阻断UHRF1与LIG1的相互作⽤，⼲扰DNA甲基化，可⽤

于癌症领域的研究[1]。

REFERENCES

[1].KoriS,etal.Structure-basedscreeningcombinedwithcomputationalandbiochemicalanalysesidentifiedtheinhibitortargetingthe

bindingofDNALigase1toUHRF1.BioorgMedChem.2021Dec15;52:116500.

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