Nigericin-sodium-salt-Standard-生命科学试剂-MCE.pdf

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Nigericin(sodiumsalt)(Standard)

Cat.No.:HY-100381R

CASNo.:28643-80-3

分⼦式:C₄₀H₆₇NaO₁₁

分⼦量:746.94

作⽤靶点:PotassiumChannel;NOD-likeReceptor(NLR);Bacterial;

Antibiotic;Pyroptosis;Wnt;β-catenin

作⽤通路:MembraneTransporter/IonChannel;

Immunology/Inflammation;Anti-infection;Apoptosis;Stem

Cell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Nigericin(sodiumsalt)(Standard)是Nigericin(sodiumsalt)的分析标准品。本产品⽤于研究及分析应⽤。

Nigericinsodiumsalt是⼀种抗⽣素(antibiotic)，源⾃Streptomyceshygroscopicus，充当K+/H+离⼦载体(

K+/H+ionophore)，促进K+/H+跨线粒体膜交换。Nigericinsodiumsalt是NLRP3的激活剂。Nigericin

sodiumsalt通过降低细胞内pH(pHi)和Wnt/β-catenin通路信号⽽显⽰出良好的抗癌活性。Nigericin

sodiumsalt在TNBC中通过caspase1/GSDMD途径诱导细胞焦亡(pyroptosis)。

体外研究Nigericin(0-4μg/mL;24h)sodiumsaltinducespyroptosisthroughcaspase1/GSDMDpathwayinTNBC

cells[6].

Nigericin(1μg/mL,8×MIC;2μg/mL,16×MIC;196h)sodiumsaltisabactericidalantibioticagainstMDR

gram-positivebacteria[4].

Nigericin(0-0.25μg