Diclofenac-amide-生命科学试剂-MCE.pdf

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Diclofenacamide

Cat.No.:HY-134521

CASNo.:15362-40-0

分⼦式:C₁₄H₉Cl₂NO

分⼦量:278.14

作⽤靶点:COX

作⽤通路:Immunology/Inflammation

储存⽅式:Powder-20°C3years

4°C2years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性Diclofenacamide是Diclofenacsodium(HY-15037)的前药。Diclofenacamide是⼝服有效的COX-1/2抑制

剂，可抑制前列腺素(PG)和⾎栓素(TX)的产⽣。Diclofenacamide在Carrageenan(HY-125474)诱发的⼤⿏

⽖⽔肿模型中表现出抗炎作⽤，且不会引起胃溃疡(300μmol/kg)。

REFERENCES

[1].SantosJL,etal.,Pharmacologicalevaluationandpreliminarypharmacokineticsstudiesofanewdiclofenacprodrugwithoutgastric

ulcerationeffect.IntJMolSci.2012Nov19;13(11):15305-20.

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