Ocifisertib-hydrochloride-CFI-400945-hydrochloride-生命科学试剂-MCE.pdf

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Ocifisertibhydrochloride

Cat.No.:HY-12300A

CASNo.:1338799-83-9

Synonyms:CFI-400945hydrochloride

分⼦式:C₃₃H₃₅ClN₄O₃

分⼦量:571.11

作⽤靶点:Polo-likeKinase(PLK);Apoptosis

作⽤通路:CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Ocifisertibhydrochloride(CFI-400945hydrochloride)是Ocifisertib(HY-12300)的盐酸盐形式。Ocifisertib

hydrochloride是⼝服有效的PLK4抑制剂，Ki和IC50分别为0.26nM和2.8nM。Ocifisertibhydrochloride

可抑制多种癌细胞的⽣长，在G2/M期阻滞细胞周期，并诱导细胞凋亡(apoptosis)。Ocifisertib

hydrochloride在⼩⿏模型中表现出抗肿瘤活性。

IC50TargetPLK4TRKATRKBTIE2/TEK

2.8nM(IC50)6nM(IC50)9nM(IC50)22nM(IC50)

AURKB/INCENPAURKA

98nM(IC50)140nM(IC50)

客户使⽤本产品发表的科研⽂献

•NatNanotechnol.2021Jul;16(7):830-839.

•IntJMolMed.2021Jan;47(1):151-160.

•JCancerResClinOncol.2020Nov;146(11):2871-2883.

•IrJMedSci.2022May4.

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REFERENCES

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