ANK-peptide-生命科学试剂-MCE.pdf

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ANKpeptide

Cat.No.:HY-P10844

CASNo.:929207-58-9

分⼦式:C₁₅₂H₂₄₄N₅₂O₄₆S₂

分⼦量:3600.01

Sequence:Lys-Gly-Asn-Ser-Ala-Leu-His-Val-Ala-Ser-Gln-His-Gly-His-Leu

-Gly-Cys-Ile-Gln-Thr-Leu-Val-Arg-Tyr-Gly-Ala-Asn-Val-Thr-Met

-Gln-Asn-His-Gly

SequenceShortening:KGNSALHVASQHGHLGCIQTLVRYGANVTMQNHG

作⽤靶点:AminoAcidDerivatives

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性ANKpeptide是⼀种基于单锚蛋⽩基序保守残基设计的新型肽。ANKpeptide是γ-突触核蛋⽩(SNCG)的抑制

剂，可与SNCG结合，竞争SNCG-BubR1相互作⽤，从⽽增强乳腺癌细胞对抗微管药物(如诺考达唑和紫杉醇)

的敏感性。ANKpeptide可⽤于肿瘤的研究。

REFERENCES

[1].SinghVK,etal.Synuclein-gammatargetingpeptideinhibitorthatenhancessensitivityofbreastcancercellstoantimicrotubuledrugs.

CancerRes.2007Jan15;67(2):626-33.

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