TMX-2172-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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TMX-2172

Cat.No.:HY-155218

CASNo.:2488892-09-5

分⼦式:C₄₁H₄₅BrFN₉O₁₁S

分⼦量:970.82

作⽤靶点:PROTACs;CDK

作⽤通路:PROTAC;CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性TMX-2172是CDK2和CDK5的PROTACs降解剂，其IC50分别为6.5和6.8nM。TMX-2172在癌症研究中发

挥着重要作⽤(蓝⾊：E3连接酶配体(HY-W008352);粉⾊：靶蛋⽩配体(HY-170748);⿊⾊：linker(HY-

151072))。

IC50TargetCDK2CDK5

6.5nM(IC50)6.8nM(IC50)

REFERENCES

[1].MingxingTeng,etal.DevelopmentofCDK2andCDK5DualDegraderTMX-2172.AngewChemIntEdEngl.2020Aug

10;59(33):13865-13870.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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