COX-2-IN-51-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

COX-2-IN-51

Cat.No.:HY-170585

CASNo.:3064260-49-4

分⼦式:C₂₃H₁₈F₄O₃S

分⼦量:450.45

作⽤靶点:COX;NF-κB

作⽤通路:Immunology/Inflammation;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性COX-2-IN-51(E25)是⼀种有效的COX-2抑制剂，IC50为70.7nM。COX-2-IN-51可显著抑制LPS诱导的NO

和PGE2释放、COX-2和iNOS表达以及NF-κB通路激活。COX-2-IN-51通过抑制NF-κB通路在多种⼩⿏模

型中表现出抗炎和镇痛作⽤。COX-2-IN-51的胃肠道副作⽤低于Indomethacin(HY-14397)。

IC50TargetCOX-2

70.7nM(IC50)

REFERENCES

[1].CaiN,etal.2-Trifluoromethyl-2H-chromeneethers:Thedualtriumphofanti-inflammationandanalgesiawithminimalulcerthreat.

BioorgChem.2025Jan;154:108050.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1