Arpromidine-BU-E-50-生命科学试剂-MCE.pdf

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Arpromidine

Cat.No.:HY-164430

CASNo.:106669-71-0

Synonyms:BU-E-50

分⼦式:C₂₁H₂₅FN₆

分⼦量:380.46

作⽤靶点:HistamineReceptor

作⽤通路:GPCR/GProtein;Immunology/Inflammation;Neuronal

Signaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Arpromidine(BU-E-50)是组胺H2受体(histamineH2receptor)的激动剂和组胺H1受体(histamineH1

receptor)的拮抗剂。Arpromidine显⽰出正性肌⼒效应，且引起⼼律失常的风险较⼩。Arpromidine可⽤于

充⾎性⼼⼒衰竭的研究。

IC50TargetH1ReceptorH2Receptor

REFERENCES

[1].BuschauerA.Synthesisandinvitropharmacologyofarpromidineandrelatedphenyl(pyridylalkyl)guanidines,apotentialnewclassof

positiveinotropicdrugs.JMedChem.1989Aug;32(8):1963-70.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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