Daeatal-Dynorphin-A-ethylamide-1-9-生命科学试剂-MCE.pdf

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Daeatal

Cat.No.:HY-P1625

CASNo.:103614-28-4

Synonyms:DynorphinAethylamide(1-9)

分⼦式:C₅₆H₉₃N₁₉O₁₀

分⼦量:1192.46

Sequence:Me-Tyr-Gly-Gly-Phe-Leu-Arg-{Arg(Me)}-{d-Leu}-Arg-{NH-Et}

SequenceShortening:Me-YGGFLR-{Arg(Me)}-{d-Leu}-R-{NH-Et}

作⽤靶点:OpioidReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Daeatal(DynorphinAethylamide(1-9))是⼀种⼄胺修饰的强啡肽⽚段，可⽤于镇痛、成瘾、抑郁症等研究。

DynorphinA是⼀种内源性阿⽚肽，参与中枢神经系统(CNS)的抑制性神经传递。DynorphinA是⼀种⾼效的

kappa阿⽚受体(KOR)激动剂，也是其他阿⽚受体的激动剂，如mu(MOR)和delta(DOR)。DynorphinA可

诱导神经元死亡，可⽤于神经系统疾病的相关研究。

REFERENCES

[1].HauserKF,etal.DynorphinA(1-13)neurotoxicityinvitro:opioidandnon-opioidmechanismsinmousespinalcordneurons.Exp

Neurol.1999Dec;160(2):361-75.

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