DC07090-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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DC07090

Cat.No.:HY-Q43250

CASNo.:879070-72-1

分⼦式:C₁₈H₁₄N₄O

分⼦量:302.33

作⽤靶点:Enterovirus

作⽤通路:Anti-infection

储存⽅式:Powder-20°C3years

4°C2years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性DC07090是针对⼈类肠道病毒EV713Cpro蛋⽩酶的新型强效⼩分⼦抑制剂，IC50值为21.72μM，⽆明显毒

性，CC50⼤于200μM。DC07090可抑制EV71复制，EC50值为22.09μM，Ki值为23.29μM。DC07090

还可以抑制柯萨奇病毒A16(CVA16)复制，EC50值为27.76μM。

REFERENCES

[1].Guang-HuiMa,etal.IdentificationandbiochemicalcharacterizationofDC07090asanovelpotentsmallmoleculeinhibitoragainst

humanenterovirus713Cproteasebystructure-basedvirtualscreening.EurJMedChem.2016Nov29:124:981-991.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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