DT-2-acetate-生命科学试剂-MCE.pdf

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DT-2acetate

Cat.No.:HY-P2692B

分⼦式:C₁₅₄H₂₈₇N₅₃O₅₅

分⼦量:3761.25

Sequence:Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Ar

g-Lys-Lys-Lys-Lys-Lys-His-NH2

SequenceShortening:YGRKKRRQRRRPPLRKKKKKH-NH2

作⽤靶点:PKG

作⽤通路:StemCell/Wnt

储存⽅式:Sealedstorage,awayfrommoisture

Powder-80°C2years

-20°C1year

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性DT-2acetate是⼀种有效的、选择性的cGMP依赖性蛋⽩激酶(PKG)抑制剂。DT-2acetate抑制PKG催化的磷

酸化(Ki:12.5nM)。

客户使⽤本产品发表的科研⽂献

•NatCommun.2024Jul18;15(1):6058.

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REFERENCES

[1].PinkseMWH,etal.ModeofactionofcGMP-dependentproteinkinase-specificinhibitorsprobedbyphotoaffinitycross-linkingmass

spectrometry.JBiolChem.2009Jun12;284(24):16354-16368.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.