肠道杆菌课件2.ppt

肠道杆菌;;AllbacillibelongingtoEnterobacteriaceaeareshortgram-negativerods,eithermobileornon-mobile.;AllbacillibelongingtoEnterobacteriaceaearefacultativeanaerobes.Theygrowincommonmedia.Mostoftheentericbacilliformround,convex,smoothcolonieswithdistinctedges.;Lactose（乳糖）fermentation;Results;Enterobacteriaceaehavecomplexantigenicstructures.;

CommonpathogenicmaterialsforEnterobacteriaceaeinclude:

bacterialstructures(pili,capsule)

toxins(enterotoxin,endotoxin)

;Infectionsoutsidetheintestinescausedbybacterialtranslocation;E.coliassociatedurinarytractinfection;InfectionsinsidetheintestinescausedbypathogenicE.coli

CommonsymptomsincludeGastroenteritis（肠胃炎）,diarrhea（腹泻）anddysentery（痢疾）.

Diseasetransmissionisbyfecal-oralroute（粪口途径）.;Causetraveller’sdiarrhea.

Twotypesofplasmid-encodedtoxinsareproduced:

Heatlabiletoxins(LT/耐热肠毒素)

activateadenylcyclase（腺苷环化酶）whichcatalyzeATPtocAMP

Heatstabletoxins(ST/不耐热肠毒素)

activateguanylcyclase（鸟苷环化酶）tocatalyzeGTPtocGMP

cAMP/cGMParetheintracellularsecondmessagers.Theformerincreasesthesecretionofwaterandions,andthelatterinhibitsionicuptake.

Clinicalsigns:waterydiarrhea,feverandnausea.;Commonlyassociatedwithinfantdiarrhea.

Characteristiclesionwithdestructionofmicrovilliwithoutinvasion

Clinicalsigns:fever,diarrheawithnon-bloodystools,vomitingandnausea.

;Associatedwithelderchildrenandadultdiarrhea.

Withoutflagella

Highvirulence:asmallnumberofEIECcancauseseriousillness

Clinicalsigns:Acuteinflammatoryresponsesandtissuedestruction.Producediarrheawithlittlefluid,muchbloodandmucuscontainingpolymorphonuclearcells.;EHECproducesbacteriophage-mediatedexotoxin.ThistoxiniscalledVerotoxin(VT)becauseofitscytotoxicitytoculturedVerocells.

Theillnessischaracterizedbyseriousabdominalpainanddiarrheawhichisi