泼尼松中小剂量联合来氟米特治疗老年慢性肾小球肾炎的效果及不良反应发生率分析.docx

泼尼松中小剂量联合来氟米特治疗老年慢性肾小球肾炎的效果及不良反应发生率分析\o分享到微博\o分享到微信\o分享到QQ\o分享到QQ空间

【摘要】目的：探究老年慢性肾小球肾炎患者采用泼尼松中小剂量+来氟米特双重治疗的临床效果。方法：选取我院确诊为慢性肾小球肾炎老年患者70例，纳入区间段2022年10月—2023年10月，经计算机分组处理，参照组推行盐酸贝那普利+双嘧达莫治疗，归入35例；实验组推行泼尼松中小剂量+来氟米特治疗，归入35例。对两组临床治疗效果进行分析。结果：实验组治疗有效率为94.29%，明显高于参照组的74.29%，差异显著，P0.05；治疗后，两组肾功能指标较治疗前改善，且实验组改善效果优于参照组，差异显著，P0.05；实验组的不良反应发生概率达到5.71%，明显低于参照组的28.57%，差异显著，P0.05。结论：慢性肾小球肾炎老年患者在治疗期间施以泼尼松中小剂量+来氟米特治疗方案的效果较为理想，不容易出现不良反应，促进患者肾功能的恢复，控制病情发展。

【关键词】泼尼松；来氟米特；慢性肾小球肾炎；老年患者；不良反应

Analysisoftheeffectandincidenceofadversereactionsoflowandmoderatedosesofprednisonecombinedwithleflunomideinthetreatmentofelderlychronicglomerulonephritis

LULei

ShandongYantaiLongkouHospitaloftraditionalChinesemedicine，Yantai，Shandong265700，China

【Abstract】Objective：Toexploretheclinicaleffectofdualtreatmentwithsmallandmediumdosesofprednisoneandleflunomideinelderlypatientswithchronicglomerulonephritis.Methods：70elderlypatientsdiagnosedwithchronicglomerulonephritisinourhospitalwereselectedandincludedintheintervalfromOctober2022toOctober2023.Aftercomputergrouping，thereferencegroupwastreatedwithbenazeprilhydrochlorideanddipyridamole，with35casesincluded；Theexperimentalgroupwastreatedwithsmallandmediumdosesofprednisoneandleflunomide，Umpv9uMAv/i3yt+v5KEADg==with35casesincluded.Theclinicaltreatmenteffectsofthetwogroupswereanalyzed.Results：Theeffectiverateoftreatmentintheexperimentalgroupwas94.29%，significantlyhigherthan74.29%inthereferencegroup，withasignificantdifference，P0.05；Aftertreatment，therenalfunctionindicatorsofbothgroupsimprovedcomparedtobeforetreatment，andtheimprovementeffectoftheexperimentalgroupwasbetterthanthatofthereferencegroup，withasignificantdifference，P0.05；Theprobabilityofadversereactionsintheexperimentalgroupreached5.71%，significantlylowerthan28.57%inthereferencegroup，withasignificantdiff