新生儿出生缺陷相关因素分析及预防措施.docx

新生儿出生缺陷相关因素分析及预防措施\o分享到微博\o分享到微信\o分享到QQ\o分享到QQ空间

【摘要】目的：分析新生儿出生缺陷相关因素，并对预防措施进行探讨。方法：选取2020年1月—2022年12月期间在全区出生的发生出生缺陷的628例患儿作为观察组，同时选取同期出生的628例健康新生儿作为对照组。收集两组的基本资料，分析出生缺陷的影响因素。结果：观察组产妇年龄35岁、孕期患病、孕期服用药物及异常生育史比例高于对照组，孕前保健、孕早期服用叶酸及规律服用叶酸比例低于对照组（P0.05）；Logistic回归分析显示，年龄35岁、未接受孕前保健、孕早期未服用叶酸、叶酸应用不规律、孕期患病、孕期服用药物及有异常生育史是发生出生缺陷的危险因素（P0.05）。结论：未接受孕前保健、高龄产妇、孕早期未使用或未规律使用叶酸、患病、用药及异常生育史均是出生缺陷的危险因素，应针对以上因素采取针对性的预防措施，做好优生优育工作。

【关键词】新生儿；出生缺陷；影响因素；预防

Analysisoffactorsrelatedtobirthdefectsinnewbornsandexplorationofpreventivemeasures

LIUYaqian

ZhangdianDistrictMaternalandChildHealthHospital，ZiboCity，Shandong，Zibo，Shandong255000，China

【Abstract】Objective：Toanalyzethefactorsrelatedtobirthdefectsinnewbornsandexplorepreventivemeasures.Methods：628childrenwithbirthdefectsbornintheentireregionbetweenJanuary2020andDecember2022wereselectedastheobservationgroup，while628healthynewbornsborninthesameperiodwereselectedasthecontrolgroup.Collectingbaselinedatafromtwogroupsandanalyzingtheinfluencingfactorsofbirthdefects.Results：Theproportionofparturientsagedover35yearsold，withpregnancyrelatedillnesses，medicationuseduringpregnancy，andabnormalfertilityhistoryintheobservationgroupwashigherthanthatinthecontrolgroup，whiletheproportionofprepregnancyhealthcare，earlypregnancyfolicaciduse，andregularfolicacidusewaslowerthanthatinthecontrolgroup（P0.05）；Logisticregressionanalysisshowedthatage35yearsold，failuretoreceiveprepregnancycare，failuretotakefolicacidinearlypregnancy，irregularuseoffolicacid，pregnancyrelatedillnesses，medicationuseduringpregnancy，andahistoryofabnormalfertilitywereriskfactorsforbirthdefects（P0.05）.Conclusion：Failuretoreceiveprepregnancycare，advancedmaternalage，failuretouseorirregularlyusingfolicacidinearlypregnancy，illness，medicationuse，andahistoryofabnormalfertilityareallrisk