6R-Leucovorin-6R-Folinic-acid-生命科学试剂-MCE.pdf

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(6R)-Leucovorin

Cat.No.:HY-126733

CASNo.:73951-54-9

Synonyms:(6R)-Folinicacid

分⼦式:C₂₀H₂₃N₇O₇

分⼦量:473.44

作⽤靶点:DrugDerivative

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(6R)-Leucovorin是叶酸(FolicAcid)的⼀种衍⽣物，叶酸是⼀种维⽣素，在DNA合成、DNA修复及DNA甲基

化过程中发挥重要作⽤，并且在涉及叶酸的⽣物反应中充当辅因⼦[1][2]。

REFERENCES

[1].ZittounJ,etal.Comparativeeffectof6S,6Rand6RSleucovorinonmethotrexaterescueandonmodulationof5-fluorouracil.BrJ

Cancer.1991Jun;63(6):885-8.

[2].LiuK,etal.Simultaneousdeterminationof6R-leucovorin,6S-leucovorinand5-methyltetrahydrofolateinhumanplasmausingsolid

phaseextractionandchiralliquidchromatography-tandemmassspectrometry.JChromatogrBAnalytTechnolBiomedLifeSci.2009Apr

1;877(10):902-10.

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