Oxomemazine-hydrochloride-生命科学试剂-MCE.pdfVIP

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Oxomemazinehydrochloride

Cat.No.:HY-167633

CASNo.:4784-40-1

分⼦式:C₁₈H₂₃ClN₂O₂S

分⼦量:366.91

作⽤靶点:mGluR;HistamineReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling;

Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Oxomemazinehydrochloride是⼀种基于吩噻嗪的组胺H1受体(histamineH1-receptor)阻滞剂，具有明显

的抗毒蕈碱活性。Oxomemazine是毒菌碱M1受体的选择性拮抗剂，在⾼(histamineH1-receptor=84nM,

M1受体)和低(histamineH1-receptor=1.65μM,M2受体)亲和⼒位点上显⽰了20倍的差异。Oxomemazine

是⼀种⽤于咳嗽研究相关研究的⼀种抗组胺和抗胆碱能试剂。

IC50TargetmGluR1mGluR2

84nM(Ki)1.65μM(Ki)

REFERENCES

[1].SWLee,etal.SelectivityofoxomemazinefortheM1muscarinicreceptors.ArchPharmRes.1994Dec;17(6):443-51.

[2].MSSiddegowda,etal.Oxomemazinehydro-chloride.ActaCrystallogrSectEStructRepOnline.2011Aug1;67(Pt8):o1875.

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