Imiquimod-d7-R-837-d-sub-7-sub-生命科学试剂-MCE.pdfVIP

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Imiquimod-d7

Cat.No.:HY-B0180S2

Synonyms:R837-d7

分⼦式:C₁₄H₉D₇N₄

分⼦量:247.35

作⽤靶点:Isotope-LabeledCompounds;Toll-likeReceptor(TLR);

Autophagy;HSV;SARS-CoV

作⽤通路:Others;Immunology/Inflammation;Autophagy;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Imiquimod-d7(R837-d7)是氘代标记的Imiquimod.Imiquimod(R837)是⼀种toll样受体7(TLR7)激动剂

，作为⼀种免疫反应修饰剂。Imiquimod在体内表现出抗病毒和抗肿瘤作⽤。Imiquimod可⽤于外⽣殖器、

肛周疣、癌症和COVID-19的研究[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].AthinaAngelopoulou,etal.Imiquimod-Atolllikereceptor7agonist-IsanidealoptionformanagementofCOVID19.EnvironRes.

2020Sep;188:109858.

[3].AdityaKGupta,etal.Imiquimod:areview.J