Antitumor-agent-200-生命科学试剂-MCE.pdf

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Antitumoragent-200

Cat.No.:HY-173182

CASNo.:3046118-64-0

分⼦式:C₁₉H₂₁FN₂O₃S

分⼦量:423.34

作⽤靶点:Microtubule/Tubulin;P-glycoprotein

作⽤通路:CellCycle/DNADamage;Cytoskeleton;Membrane

Transporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Antitumoragent-200(Compound2g)是⼀种微管合成抑制剂，通过与与微管蛋⽩秋⽔仙碱位点结合，导致

G2/M细胞周期停滞，并产⽣ROS。Antitumoragent-200对P-糖蛋⽩(P-gp)过表达的MCF7/ADR和KBV200

细胞系具有显著的抑制活性，耐药指数(DRI)分别为0.83和0.58。在MCF-7异种移植模型中，Antitumor

agent-200(25mg/kg，腹腔注射)可达到57.2%的肿瘤⽣长抑制率。Antitumoragent-200可⽤于抗癌领域的

研究[1]。

REFERENCES

[1].JiangB,etal.Identificationofselenium-containingbenzamidesaspotentmicrotubule-targetingantitumoragents.BioorgChem.2025

Mar10;159:108355.

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