CDK4-6-BRD4-IN-1-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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CDK4/6/BRD4-IN-1

Cat.No.:HY-173237

分⼦式:C₄₁H₄₃FN₁₀O₆

分⼦量:790.84

作⽤靶点:CDK;EpigeneticReaderDomain

作⽤通路:CellCycle/DNADamage;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CDK4/6/BRD4-IN-1(B15)是⼀种针对CDK4、CDK6和BRD4的抑制剂，对BRD4-BD2、BRD4-BD1、CDK6和

CDK4的IC50值分别为220nM、146nM、106nM和85nM。CDK4/6/BRD4-IN-1(B15)可⽤于⾮⼩细胞肺

癌(NSCLC)的研究。CDK4/6/BRD4-IN-1(B15)能够诱导细胞周期阻滞和细胞凋亡。

IC50TargetCDK4CDK6BD2BD1

85nM(IC50)106nM(IC50)220nM(IC50)146nM(IC50)

REFERENCES

[1].YongleiZhang,etal.DiscoveryofdualCDK4/6andBRD4inhibitorasapoptosisandautophagyinducersagainstNSCLCinvitroandin

vivo.EurJMedChem.2025Jun5:290:117495.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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