Dihydrochalcone-3-Phenylpropiophenone-生命科学试剂-MCE.pdfVIP

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Dihydrochalcone

Cat.No.:HY-114508

CASNo.:1083-30-3

Synonyms:3-Phenylpropiophenone;β-Phenylpropiophenone

分⼦式:C₁₅H₁₄O

分⼦量:210.27

作⽤靶点:Amyloid-β

作⽤通路:NeuronalSignaling

储存⽅式:Storeatroomtemperature3years

*Insolvent:-80°C,6months;-20°C,1month(Storeatroom

temperature3years)

BIOLOGICALACTIVITY

⽣物活性Dihydrochalcone(3-Phenylpropiophenone)是⼀种可穿透⾎脑屏障(BBB)的Aβ聚集抑制剂。

Dihydrochalcone通过破坏β1区的β折叠，使Aβ17-42原纤维不稳定。Dihydrochalcone通过与原纤维空

腔(cavity)结合，使U型Aβ40/Aβ42原纤维和S型Aβ42原纤维不稳定。Dihydrochalcone是龙葵(

daemonoropsdraco)树的主要成分。

REFERENCES

[1].JinY,etal.DihydrochalconemoleculesdestabilizeAlzheimersamyloid-βprotofibrilsthroughbindingtotheprotofibrilcavity.PhysChem

ChemPhys.2018Jun27;20(25):17208-17217.

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