Sabeluzole-Standard-R-58735-Standard-生命科学试剂-MCE.pdfVIP

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Sabeluzole(Standard)

Cat.No.:HY-105022R

CASNo.:104383-17-7

Synonyms:R58735(Standard)

分⼦式:C₂₂H₂₆FN₃O₂S

分⼦量:415.52

作⽤靶点:TauProtein

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Sabeluzole(Standard)是Sabeluzole的分析标准品。本产品⽤于研究及分析应⽤。Sabeluzole(R58735)是⼀

种苯并噻唑衍⽣物，具有抗缺⾎、抗癫痫和增强认知的特性。Sabeluzole通过阻⽌tau表达保护⼤⿏海马神经

元免受NMDA和⾕氨酸诱导的神经毒性。Sabeluzole增强⼤⿏的记忆⼒，并防⽌Chlordiazepoxide的遗忘效

应。Sabeluzole可⽤于阿尔茨海默病研究。

REFERENCES

[1].HlinákZ,etal.Sabeluzoleimprovessocialrecognitionandantagonizeschlordiazepoxideseffectonhabituationintherat.

Psychopharmacology(Berl).1991;104(4):505-9.

[2].UbertiD,etal.Primingofculturedneuronswithsabeluzoleresultsinlong-lastinginhibitionofneurotoxin-inducedtauexpressionandcell

death.Synapse.1997Jun;26(2):95-103.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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