Lerisetron-Standard-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Lerisetron(Standard)

Cat.No.:HY-105090R

CASNo.:143257-98-1

分⼦式:C₁₈H₂₀N₄

分⼦量:292.39

作⽤靶点:5-HTReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Lerisetron(Standard)是Lerisetron的分析标准品。本产品⽤于研究及分析应⽤。Lerisetron是⼀种有效的5-

HT3拮抗剂，与5-HT3受体具有⾼亲和⼒，pKi为9.2。Lerisetron在尿烷⿇醉⼤⿏中能有效抑制5-HT诱发的

反射性⼼率过缓[1]。

IC50TargetpKi:9.2(5-HT3)[1]

REFERENCES

[1].OrjalesA,MosqueraR,LabeagaL,RodesR.New2-piperazinylbenzimidazolederivativesas5-HT3antagonists.Synthesisand

pharmacologicalevaluation.JMedChem.1997;40(4):586-593.

[2].JauregizarN,CalvoR,SuarezE,QuintanaA,RaczkaE,LukasJC.Pharmacokineticsandpharmacologicaleffectoflerisetron,anew5-

HT3antagonist,inrats.JPharmSci.2002;91(1):41-52.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Te