Zacopride-hydrochloride-Standard-生命科学试剂-MCE.pdf

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Zacopridehydrochloride(Standard)

Cat.No.:HY-103137R

CASNo.:101303-98-4

分⼦式:C₁₅H₂₁Cl₂N₃O₂

分⼦量:346.25

作⽤靶点:5-HTReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Zacopride(hydrochloride)(Standard)是Zacopride(hydrochloride)的分析标准品。本产品⽤于研究及分析应

⽤。Zacopridehydrochloride是⼀种⾼效的5-HT3受体拮抗剂，5-HT3和5-HT4受体Kis值分别为0.38和

373nM。Zacopridehydrochloride也是⼀种中度的IK1通道激动剂。Zacopridehydrochloride具有显着的抗

⼼律失常和⼼脏保护作⽤[1][2][3]。

REFERENCES

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[2].PinkusLM,etal.UtilizationofZacoprideanditsR-andS-EnantiomersinStudiesof5-HT3Receptor“Subtypes”.Serotonin:Molecular

Biology,ReceptorsandFunctionalEffects,1991:439-448.

[3].NagakuraY,etal.Pharmacologicalpropertiesofanovelgastrointestinalprokineticbenzamideselectiveforhuman5-HT4receptor

versushuman5-HT3receptor.PharmacolRes.1999May;39(5):375-82.

[4].SancilioLF,etal.Emeticactivityofzacoprideinferretsanditsantagonismbypharmacologicalagents.EurJPharmacol.1990Jun

8;181(3):303-6.

[5].