Cilostazol-d2-OPC-13013-d-sub-2-sub-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Cilostazol-d2

Cat.No.:HY-17464S2

CASNo.:1073608-03-3

Synonyms:OPC13013-d2

分⼦式:C₂₀H₂₅D₂N₅O₂

分⼦量:371.47

作⽤靶点:Isotope-LabeledCompounds;Autophagy;Phosphodiesterase

(PDE)

作⽤通路:Others;Autophagy;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Cilostazol-d2(OPC13013-d2)是氘代标记的Cilostazol.Cilostazol(OPC13013)是有效、选择性的⼼⾎管系统

中磷酸⼆酯酶3亚型PDE3A的抑制剂，IC50值为0.2μM[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.