Cladribine-15N-2-Chloro-2-deoxyadenosine-sup-15-sup-N-生命科学试剂-MCE.pdf

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Cladribine-15N

Cat.No.:HY-13599S2

CASNo.:1360874-38-9

Synonyms:2-Chloro-2′-deoxyadenosine-15N;Cldado-15N;2Cda-15N

分⼦式:C₁₀H₁₂ClN₄₁₅NO₃

分⼦量:286.68

作⽤靶点:Isotope-LabeledCompounds;Apoptosis;Adenosine

Deaminase

作⽤通路:Others;Apoptosis;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Cladribine-15N(2-Chloro-2′-deoxyadenosine-15N)是15N标记的Cladribine.Cladribine(2-Chloro-2′-

deoxyadenosine)是⼀种嘌呤核苷类似物，是具有⼝服活性的腺苷脱氨酶(adenosinedeaminase)抑制剂。

Cladribine能作为DNA合成(DNAsynthesis)的抑制剂，可阻断受损DNA的修复。Cladribine可以抑制DNA

甲基化。Cladribine具有抗淋巴瘤活性，可⽤于⼀些⾎液恶性肿瘤和多发性硬化的研究[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].LinyanXu,etal.CladribineInduces