Naloxegol-13C-d3-NKTR-118-sup-13-sup-C-sub-d-sub-3-sub-生命科学试剂-MCE.pdf

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Naloxegol-13C,d3

Cat.No.:HY-A0118S

Synonyms:NKTR-118-13C,d;AZ13C

3,d3

分⼦式:C₃₃₁₃CH₅₀D₃NO₁₁

分⼦量:655.8

作⽤靶点:Isotope-LabeledCompounds

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Naloxegol-13C,d3(NKTR-118-13C,d3)是13C标记的Naloxegol.Naloxegol(NKTR-118;AZ是⼀

种μ-阿⽚受体拮抗剂。Naloxegol能抑制阿⽚结合胃肠道μ-阿⽚受体，能有效减轻阿⽚类药物引起的便秘

[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacoth