Fluralaner-d2-A1443-d-sub-2-sub-生命科学试剂-MCE.pdfVIP

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Fluralaner-d2

Cat.No.:HY-16973S5

Synonyms:A1443-d;AH252723-d

22

分⼦式:C₂₂H₁₅D₂Cl₂F₆N₃O₃

分⼦量:558.3

作⽤靶点:Isotope-LabeledCompounds;Parasite

作⽤通路:Others;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Fluralaner-d2(A1443-d2)是氘代标记的Fluralaner.Fluralaner(INN)是⼀种全⾝性杀⾍剂和杀螨剂，通过有效

阻断GABA和L-glutamate氯化物通道。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].WilliamsH,etal.Fluralaner,anovelisoxazoline,preventsflea(Ctenocep