Ponesimod-Standard-ACT-128800-Standard-生命科学试剂-MCE.pdf

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Ponesimod(Standard)

Cat.No.:HY-10569R

CASNo.:854107-55-4

Synonyms:ACT-128800(Standard)

分⼦式:C₂₃H₂₅ClN₂O₄S

分⼦量:460.97

作⽤靶点:LPLReceptor

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Ponesimod(Standard)是Ponesimod的分析标准品。本产品⽤于研究及分析应⽤。Ponesimod(ACT-128800)

是⼀种有效的，具有选择性和⼝服活性的S1P1的激动剂，在放射性配体结合试验中的IC50值为6nM。

Ponesimod可⾼效激活S1P1介导的信号转导(EC50=5.7nM)。Ponesimod可以预防淋巴细胞介导的组织炎症

。

REFERENCES

[1].PialiL,etal.Theselectivesphingosine1-phosphatereceptor1agonistponesimodprotectsagainstlymphocyte-mediatedtissue

inflammation.JPharmacolExpTher.2011May;337(2):547-56.

[2].BolliMH,etal.2-imino-thiazolidin-4-onederivativesaspotent,orallyactiveS1P1receptoragonists.JMedChem.2010May

27;53(10):4198-211.

[3].BrossardP,etal.Pharmacokineticsandpharmacodynamicsofponesimod,aselectiveS1P1receptormodulator,inthefirst-in-human

study.BrJClinPharmacol.2013Dec;76(6):888-96.

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