BCX-3607-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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BCX-3607

Cat.No.:HY-172905

CASNo.:885684-79-7

分⼦式:C₂₇H₂₉N₅O₃

分⼦量:471.55

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BCX-3607是⼀种⼝服有效的组织因⼦/因⼦VIIa(TF-FVIIa)抑制剂(IC50:4nM)。BCX-3607通过抑制TF-FVIIa

复合物阻断外源性凝⾎途径，显著延长凝⾎酶原时间(PT)。BCX-3607对TF-FVIIa的选择性⾼于其他丝氨酸蛋

⽩酶(如凝⾎酶、FXa等)。BCX-3607能够减少⾎栓重量和炎症反应，具有抗⾎栓和抗炎双重作⽤。BCX-3607

可⽤于⾎栓相关疾病的研究[1]。

IC50TargetTF-FVIIa

REFERENCES

[1].KotianPL,etal.Design,synthesis,andstructure-activityrelationshipsofselectivebiphenylantithrombotictissuefactor/factorVIIa

inhibitors.EurJMedChem.2025May6;294:117708.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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