PD-L1-inhibitory-peptide-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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PD-L1inhibitorypeptide

Cat.No.:HY-P10950

CASNo.:1931111-41-9

分⼦式:C₉₆H₁₃₅N₂₁O₂₃S

分⼦量:1983.29

Sequence:Ac-Tyr-{NMe-Ala}-Asn-Pro-Dap-Leu-Hyp-Trp-Dab-Trp{CH2CO

OH}-{NMe-Nle}-{NMe-Nle}-Leu-Cys-Gly-{L-Propargylglycine}(t

hioetherbridge:Tyr1-Cys15)

作⽤靶点:PD-1/PD-L1

作⽤通路:Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PD-L1inhibitorypeptide是⼀种抑制剂肽，靶向程序性细胞死亡配体1(PD-L1)。PD-L1inhibitorypeptide结

合PD-L1，解除免疫抑制，恢复T细胞的抗肿瘤活性。PD-L1inhibitorypeptide有望⽤于肿瘤的研究[1][2]。

REFERENCES

[1].ShindoY,etal.Anti-PD-L1peptideimprovessurvivalinsepsis[J].JournalofSurgicalResearch,2017,208:33-39.

[2].BoohakerRJ,etal.RationaldesignanddevelopmentofapeptideinhibitorforthePD-1/PD-L1interaction.CancerLett.2018Oct

10;434:11-21.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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