华东地区早发胃癌特异性分子标志物的多组学整合分析.pdfVIP

2032李竞娆，等华东地区早发胃癌特异性分子标志物的多组学整合分析

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华东地区早发胃癌特异性分子标志物的多组学整合分析

李竞，丁诗韵，武文汇，毛嘉宁，郑吉13,王梦筠”，张若昕1.3

1复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室，上海200032；²复旦大学

肿瘤研究所，复旦大学附属肿瘤医院，上海200032；3复旦大学义乌研究院，浙江义乌322000

目的：寻找早发胃癌特异性标志基因，并探究标志基因遗传变异与华东地区早发胃癌发病风险的

【摘要】目

关联。方法：研究利用多个胃癌组学研究中东亚人群数据，从拷贝数变异（copynumberaberrations，CNAs）

和转录组差异表达（differentiallyexpressedgenes,DEGs）两个水平整合分析早发胃癌特异的候选基因。通

过单因素和多因素Logistic回归评估候选基因表达与早