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PD98059(Standard)

Cat.No.:HY-12028R

CASNo.:167869-21-8

分⼦式:C₁₆H₁₃NO₃

分⼦量:267.28

作⽤靶点:MEK;ERK;ArylHydrocarbonReceptor;Autophagy

作⽤通路:MAPK/ERKPathway;StemCell/Wnt;

Immunology/Inflammation;Autophagy

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PD98059(Standard）是PD98059的分析标准品。本产品⽤于研究及分析应⽤。PD98059是⼀种有效的选择

性的MEK抑制剂，IC50为5μM。PD98059与MEK的⽆活性形式结合，从⽽阻⽌上游激酶激活MEK1(IC50

为2-7μM)和MEK2(IC50为50μM)。PD98059是⼀种ERK1/2信号的抑制剂。PD98059是⼀种芳烃受体(

AHR)的配体，可抑制细胞中TCDD结合(IC50为4μM)和AHR转化(IC50为1μM)。PD98059还可抑制

MycobacteriumbovisBacillusCalmetteGuerin(BCG)诱导的细胞⾃噬(autophagy)。

IC50TargetIC50:2-7μM(MEK1),50μM(MEK2)[1]

REFERENCES

[1].ReinersJJJr,etal.PD98059isanequipotentantagonistofthearylhydrocarbonreceptorandinhibitorofmitogen-activatedprotein

kinasekinase.MolPharmacol.1998Mar;53(3):438-45.

[2].AlessiDR,etal.PD098059isaspecificinhibitoroftheactivationofmitogen-activatedproteinkinasekinaseinvitroandinvivo.JBiol

Chem,1995,270(46),27489-27494.

[3].DiPaolaR,etal.PD98059,aspecificMAPkinaseinhibitor,attenuatesmultipleorgandysfun