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Nefazodone(Standard)

Cat.No.:HY-119209R

CASNo.:83366-66-9

分⼦式:C₂₅H₃₂ClN₅O₂

分⼦量:470.01

作⽤靶点:5-HTReceptor;CytochromeP450

作⽤通路:GPCR/GProtein;NeuronalSignaling;Metabolic

Enzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Nefazodone(Standard）是Nefazodone的分析标准品。本产品⽤于研究及分析应⽤。Nefazodone是⼀种具

有⼝服活性的苯基哌嗪类抗抑郁剂。Nefazodone可有效、选择性地阻断突触后5-HT2A受体，适度抑制5-HT

和去甲肾上腺素(noradrenaline)再摄取。Nefazodone还可以缓解应激反应对⼩⿏免疫系统的不良影响。

Nefazodone对CYP3A4同⼯酶具有较⾼的亲和⼒，表明其存在⼀定的活性分⼦-活性分⼦相互作⽤风险。

IC50Target5-HTreceptor,Noradrenaline,CYP3A4[1]

REFERENCES

[1].DykensJA,etal.Invitroassessmentofmitochondrialdysfunctionandcytotoxicityofnefazodone,trazodone,andbuspirone.ToxicolSci.

2008Jun;103(2):335-45.

[2].Freire-GarabalM,etal.Effectsofnefazodoneontheimmunesystemofmice.EurNeuropsychopharmacol.2000Jul;10(4):255-64.

[3].DavisR,etal.Areviewofitspharmacologyandclinicalefficacyinthemanagementofmajo